Charles and Louella Snyder Laboratory for Retinal Regeneration

Jeffrey M. Gross, PhD
Jeffrey M. Gross, PhD

Led by Jeffrey M. Gross, PhD, the E. Ronald Salvitti Chair in Ophthalmology Research, the Charles and Louella Snyder Laboratory for Retinal Regeneration was formed through the culmination of a series of generous contributions by Charles and Louella Snyder and their family foundation.

Dr. Gross and his team focuses their research on ocular development, disease and regeneration, and utilizes the zebrafish, Danio rerio, as a model system for most of their studies. The zebrafish is an ideal model through which genes necessary for visual system development, function and regeneration can been identified. Zebrafish embryos are transparent during early development and their eyes are large and easily accessible. Furthermore, eye development in zebrafish is analogous to that observed in other vertebrate embryos, and their eyes are structurally similar to the human eye, thereby providing an excellent model system in which one can address fundamental aspects of eye development. Indeed, many disrupted genes and pathways identified as integral to the formation of the zebrafish eye produce phenotypes that resemble disorders of the human visual system.

Thus, characterization of the molecular mechanisms of eye development in zebrafish promises to facilitate a better understanding of these human pathologies. Moreover, the zebrafish regenerates its retina after injury making this an ideal system through which the molecular underpinnings of the regenerative process can be elucidated, and potential therapies developed and/or tested. The goal is to progress towards understanding the epigenetic regulation of retinal development from progenitor cell to differentiated neuron, and how these processes could operate during regeneration.

The Charles and Louella Snyder Lab will work in tandem with the Louis J. Fox Center for Vision Restoration by partnering with other tissue engineers, geneticists, and ophthalmic researchers in order to innovate within the fields of regenerative technology and medicine, to help find new treatments and cures for diseases and disorders of the eye.